Biomarkers Endometrium
The following list has been reviewed and approved by the European Society of Urogenital Radiology’s (ESUR)’s Women’s Pelvic Imaging Group.
UTERUS |
Technique |
Level of |
Single centre/ |
Indication |
Patient prep |
Data acquisition |
Image processing |
Recommended |
Size/ Morphology
|
12-5! |
Single centre & Multicentre |
Detection, staging, treatment response |
IM antiperistaltic agent |
Sagittal, axial and coronal oblique |
Manual documentation by trained observer |
|
DCE-MRI
|
15-9! |
Single centre |
Staging |
IM antiperistaltic agent |
3D fat-saturated T1W 2min30s after contrast medium administration |
Manual documentation by trained observer |
DWI (visual)
|
15, 10! |
Single centre |
Staging |
IM antiperistaltic agent |
At least 2 b-values (b=0-50 and b=800-1000 s/mm2) |
Manual documentation by trained observer |
|
Biomarkers in development/ |
ADC and ADC histogram |
111, 12! |
Single centre |
Differentiation benign and malignant, staging, histopathological tumour features |
IM antiperistaltic agent |
At least 2 b-values (b=0-50 and b=800-1000 s/mm2) |
Monoexponential data fit, first order histogram parameters |
Multiparametric MR
|
317! |
Single centre |
Staging and histopathological tumour features |
IM antiperistaltic agent |
At least 2 b-values (b=0-50 and b=800-1000 s/mm2) |
Monoexponentional data fit, first order histogram parameters |
|
Radiomics
|
318! |
Single centre |
Histopathological tumour features |
IM anitperistaltic agent |
T2W, DWI and dynamic DCEs |
No consensus available |
- Schweitzer ME. Evidence level. J Magn Reson Imaging. 2016;43(3):543-543. doi:10.1002/jmri.25187
- Hricak H, Rubinstein L V, Gherman GM, Karstaedt N. MR imaging evaluation of endometrial carcinoma: results of an NCI cooperative study. Radiology. 1991;179(3):829-832. doi:10.1148/radiology.179.3.2028000
- Hricak H, Stern JL, Fisher MR, Shapeero LG, Winkler ML, Lacey CG. Endometrial carcinoma staging by MR imaging. Radiology. 1987;162(2):297-305. doi:10.1148/radiology.162.2.3797641
- Nougaret S, Horta M, Sala E, et al. Endometrial Cancer MRI staging: Updated Guidelines of the European Society of Urogenital Radiology. Eur Radiol. July 2018. doi:10.1007/s00330-018-5515-y
- Lavaud P, Fedida B, Canlorbe G, Bendifallah S, Darai E, Thomassin-Naggara I. Preoperative MR imaging for ESMO-ESGO-ESTRO classification of endometrial cancer. Diagn Interv Imaging. 2018 Jun;99(6):387-396. doi: 10.1016/j.diii.2018.01.010. Epub 2018 Feb 19. PubMed PMID: 29472031.
- Hricak H, Hamm B, Semelka RC, et al. Carcinoma of the uterus: use of gadopentetate dimeglumine in MR imaging. Radiology. 1991;181(1):95-106. doi:10.1148/radiology.181.1.1887062
- Yamashita Y, Harada M, Sawada T, Takahashi M, Miyazaki K, Okamura H. Normal uterus and FIGO stage I endometrial carcinoma: dynamic gadolinium-enhanced MR imaging. Radiology. 1993;186(2):495-501. doi:10.1148/radiology.186.2.8421757
- Frei KA, Kinkel K, Bonél HM, Lu Y, Zaloudek C, Hricak H. Prediction of Deep Myometrial Invasion in Patients with Endometrial Cancer: Clinical Utility of Contrast-enhanced MR Imaging-A Meta-analysis and Bayesian Analysis. Radiology. 2000;216(2):444-449. doi:10.1148/radiology.216.2.r00au17444
- Sironi S, Colombo E, Villa G, et al. Myometrial invasion by endometrial carcinoma: assessment with plain and gadolinium-enhanced MR imaging. Radiology. 1992;185(1):207-212. doi:10.1148/radiology.185.1.1523309
- Rechichi G, Galimberti S, Signorelli M, Perego P, Valsecchi MG, Sironi S. Myometrial invasion in endometrial cancer: diagnostic performance of diffusion-weighted MR imaging at 1.5-T. Eur Radiol. 2010;20(3):754-762. doi:10.1007/s00330-009-1597-x
- Kim H-J, Lee S-Y, Shin YR, Park CS, Kim K. The Value of Diffusion-Weighted Imaging in the Differential Diagnosis of Ovarian Lesions: A Meta-Analysis. Cao C, ed. PLoS One. 2016;11(2):e0149465. doi:10.1371/journal.pone.0149465
- Nakamura K, Imafuku N, Nishida T, et al. Measurement of the minimum apparent diffusion coefficient (ADCmin) of the primary tumor and CA125 are predictive of disease recurrence for patients with endometrial cancer. Gynecol Oncol. 2012;124(2):335-339. doi:10.1016/J.YGYNO.2011.10.014
- Tamai K, Koyama T, Saga T, et al. Diffusion-weighted MR imaging of uterine endometrial cancer. J Magn Reson Imaging. 2007;26(3):682-687. doi:10.1002/jmri.20997
- Shen S-H, Chiou Y-Y, Wang J-H, et al. Diffusion-Weighted Single-Shot Echo-Planar Imaging with Parallel Technique in Assessment of Endometrial Cancer. Am J Roentgenol. 2008;190(2):481-488. doi:10.2214/AJR.07.2155
- Fujii S, Matsusue E, Kigawa J, et al. Diagnostic accuracy of the apparent diffusion coefficient in differentiating benign from malignant uterine endometrial cavity lesions: initial results. Eur Radiol. 2008;18(2):384-389. doi:10.1007/s00330-007-0769-9
- Woo S, Cho JY, Kim SY, Kim SH. Histogram analysis of apparent diffusion coefficient map of diffusion-weighted MRI in endometrial cancer: a preliminary correlation study with histological grade. Acta radiol. 2014;55(10):1270-1277. doi:10.1177/0284185113514967
- Nougaret S, Reinhold C, Alsharif SS, et al. Endometrial Cancer: Combined MR Volumetry and Diffusion-weighted Imaging for Assessment of Myometrial and Lymphovascular Invasion and Tumor Grade. Radiology. 2015;276(3):797-808. doi:10.1148/radiol.15141212
- Ueno Y, Forghani B, Forghani R, et al. Endometrial Carcinoma: MR Imaging–based Texture Model for Preoperative Risk Stratification—A Preliminary Analysis. Radiology. 2017;284(3):748-757. doi:10.1148/radiol.2017161950