The authors of this study used preoperative CT radiomics in order to predict the tertiary lymphoid structures (TLSs) status and recurrence-free survival (RFS) of intrahepatic cholangiocarcinoma (ICC) patients. Enhanced CT images from a total of 116 ICC patients were included when using the radiomics model.
The study results showed that the radiomics nomogram displayed better performance in predicting TLSs than independent radiomics or clinical models as well as a better prognosis stratification than postoperative pathologic TLSs status in ICC patients. These results have the potential for clinical application by helping to identify patients who would benefit most from surgery and immunotherapy.
Key points:
- The combined (radiomics nomogram) model consisted of the radiomics model and clinical model (arterial phase diffuse hyperenhancement and AJCC 8th stage).
- The radiomics nomogram showed better performance in predicting TLSs than independent radiomics or clinical models in ICC patients.
- Preoperative CT radiomics nomogram achieved more accurate stratification for RFS of ICC patients than the postoperative pathologic TLSs status.
Authors: Ying Xu, Zhuo Li, Yi Yang, Lu Li, Yanzhao Zhou, Jingzhong Ouyang, Zhen Huang, Sicong Wang, Lizhi Xie, Feng Ye, Jinxue Zhou, Jianming Ying, Hong Zhao & Xinming Zhao
